Program ARDD 2021
Tuesday, August 31
04:00 – 04:45 (NY)
10:00 − 10:45 (CET)
10:00 − 10:45 (CET)
Registrations, coffee, tea
04:45 – 05:00 (NY)
10:45 − 11:00 (CET)
10:45 − 11:00 (CET)
Welcome!
Ulla Wewer, University of Copenhagen, Denmark
05:00 – 05:20 (NY)
11:00 − 11:20 (CET)
11:00 − 11:20 (CET)
AI and Its Applications in Healthcare
Kai-Fu Lee, Chairman and CEO, Sinovation Ventures
President, Sinovation Ventures Artificial Intelligence Institute
President, Sinovation Ventures Artificial Intelligence Institute
05:20 – 05:40 (NY)
11:20 − 11:40 (CET)
11:20 − 11:40 (CET)
Targeting protein fidelity for long life
Filipe Cabreiro, Imperial College London and University of Cologne – CECAD
05:40 – 06:00 (NY)
11:40 − 12:00 (CET)
11:40 − 12:00 (CET)
African turquoise killifish shed light on evolution and modulation of vertebrate lifespan
Dario Riccardo Valenzano, Max Planck Institute for Biology of Aging and Leibniz Institute on Aging, Germany
12:00 − 13:30 (CET)
Lunch
07:30 – 07:50 (NY)
13:30 − 13:50 (CET)
13:30 − 13:50 (CET)
Convergent mechanisms of longevity
Adam Antebi, Director at the Max Planck Institute for Biology of Ageing, Germany
07:50 – 08:10 (NY)
13:50 − 14:10 (CET)
13:50 − 14:10 (CET)
Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster
Alexey Moskalev, Russian academy of Sciences, Russia
08:10 – 08:30 (NY)
14:10 − 14:30 (CET)
14:10 − 14:30 (CET)
Mapping of chromatin accessibility changes reveals a new mechanism required for the longevity of C. elegans with reduced insulin/IGF-like signaling
Christian Riedel, Karolinska, Sweden
08:30 – 08:50 (NY)
14:30 − 14:50 (CET)
14:30 − 14:50 (CET)
Break
08:50 – 09:10 (NY)
14:50 − 15:10 (CET)
14:50 − 15:10 (CET)
A blueprint for intervention studies to increase healthspan in humans
Andrea Maier, Oon Chiew Seng Professor in Medicine and Functional Ageing, National University of Singapore, Professor of Gerontology Vrije Universiteit Amsterdam, The Netherlands
09:10 – 09:30 (NY)
15:10 − 15:30 (CET)
15:10 − 15:30 (CET)
The metrics of aging: the important of a longitudinal perspective
Luigi Ferrucci, NIA-NIH, USA
09:30 – 09:50 (NY)
15:30 − 15:50 (CET)
15:30 − 15:50 (CET)
System dynamics thinking in the life sciences
Rudi GJ Westendorp, Professor of Medicine at Old Age, University of Copenhagen, Denmark
09:50 – 10:00 (NY)
15:50 − 16:00 (CET)
15:50 − 16:00 (CET)
Break
10:00 – 10:20 (NY)
16:00 − 16:20 (CET)
16:00 − 16:20 (CET)
Mitochondrial dysfunction abrogates the benefits of metabolic hormesis in late life
Maria Ermolaeva, Leibniz Institute on Aging, Germany
10:20 – 10:40 (NY)
16:20 − 16:40 (CET)
16:20 − 16:40 (CET)
Hormetins as drugs for health and longevity
Suresh Rattan, Professor Emeritus of Biogerontology at the Department of
Molecular Biology and Genetics, Aarhus University, Denmark.
Molecular Biology and Genetics, Aarhus University, Denmark.
10:40 – 11:00 (NY)
16:40 − 17:00 (CET)
16:40 − 17:00 (CET)
Cellular stress responses - signals, sensors and outcomes
Simon Holst Bekker-Jensen, University of Copenhagen, Denmark
11:00 – 11:20 (NY)
17:00 − 17:20 (CET)
17:00 − 17:20 (CET)
Break
11:20 – 11:40 (NY)
17:20 − 17:40 (CET)
17:20 − 17:40 (CET)
Cell intrinsic and cell extrinsic drivers of hematopoietic stem cell aging
Emmanuelle Passegué, Columbia University, USA
11:40 – 12:00 (NY)
17:40 − 18:00 (CET)
17:40 − 18:00 (CET)
Aging, Cellular Senescence, and Senolytics: The Path to Translation
James Kirkland, Mayo Clinic, USA
12:00 – 12:20 (NY)
18:00 − 18:20 (CET)
18:00 − 18:20 (CET)
Senolytics and their cell targets
Laura Niedernhofer, University of Minnesota, USA
12:20 – 13:00 (NY)
18:20 − 19:00 (CET)
18:20 − 19:00 (CET)
Break
13:00 – 13:20 (NY)
19:00 − 19:20 (CET)
19:00 − 19:20 (CET)
100,000 longevity interventions per year: How robotics and AI can get us there in 6 months
Matt Kaeberlein, Professor of Laboratory Medicine and Pathology,
Adjunct Professor of Genome Sciences,
Adjunct Professor of Oral Health Sciences,
The University of Washington, USA
Adjunct Professor of Genome Sciences,
Adjunct Professor of Oral Health Sciences,
The University of Washington, USA
13:20 – 13:40 (NY)
19:20 − 19:40 (CET)
19:20 − 19:40 (CET)
Mechanisms of human longevity-associated genetic variants
Yousin Suh, Columbia University, USA
13:40 – 14:00 (NY)
19:40 − 20:00 (CET)
19:40 − 20:00 (CET)
Quantifying aging and rejuvenation
Vadim Gladyshev, Harvard, USA
14:00 – 15:00 (NY)
20:00 − 21:00 (CET)
20:00 − 21:00 (CET)
Poster session
Wednesday, September 1
04:00 – 04:45 (NY)
10:00 − 10:45 (CET)
10:00 − 10:45 (CET)
Registrations, coffee, tea
04:45 – 05:00 (NY)
10:45 − 11:00 (CET)
10:45 − 11:00 (CET)
Welcome!
05:00 – 05:20 (NY)
11:00 − 11:20 (CET)
11:00 − 11:20 (CET)
In vivo rejuvenation using the Yamanaka factors
Manuel Serrano, IRB Barcelona, Spain
05:20 – 05:40 (NY)
11:20 − 11:40 (CET)
11:20 − 11:40 (CET)
Targeting senescence heterogeneity in cancer and aging
Peter de Keizer, University Medical Center Utrecht, Netherlands
05:40 – 06:00 (NY)
11:40 − 12:00 (CET)
11:40 − 12:00 (CET)
Interventions in premature aging
Morten Scheibye-Knudsen, University of Copenhagen, Denmark
12:00 − 13:30 (CET)
Lunch
07:30 – 07:50 (NY)
13:30 − 13:50 (CET)
13:30 − 13:50 (CET)
Extracellular matrix remodeling during longevity
Collin Ewald, ETH Zurich, Switzerland
07:50 – 08:10 (NY)
13:50 − 14:10 (CET)
13:50 − 14:10 (CET)
Targeting common pathways to treat age-related diseases
Anne-Ulrike Trendelenburg, Research Director, Musculoskeletal Disease Area, Novartis Institutes for Biomedical Research, Cambridge, USA
08:10 – 08:30 (NY)
14:10 − 14:30 (CET)
14:10 − 14:30 (CET)
Late life interventions to extend healthspan in mice
Sarah J. Mitchell, ETH Zurich, Switzerland
08:30 – 08:50 (NY)
14:30 − 14:50 (CET)
14:30 − 14:50 (CET)
Break
08:50 – 09:05 (NY)
14:50 − 15:05 (CET)
14:50 − 15:05 (CET)
Progerin-expressing endothelial cells initiate a senescence-linked paracrine signaling causing vascular pathologies in premature aging disease
Christina Manakanatas, The University of Vienna, Austria
09:05 – 09:20 (NY)
15:05 − 15:20 (CET)
15:05 − 15:20 (CET)
Old drug, new target: Geroprotector rewriting epigenetic and proteostasis to promote gut health and longevity
Yu-Xuan Lu, Max Planck Institute for Biology of Ageing, Cologne, Germany
09:20 – 09:35 (NY)
15:20 − 15:35 (CET)
15:20 − 15:35 (CET)
Using artificial intelligence for rapid identification of mitophagy inducing drugs for the treatment of Alzheimer's disease
Alice Ruixue Ai, Department of Clinical Molecular Biology | UiO,
University of Oslo & Akershus University Hospital, Norway
University of Oslo & Akershus University Hospital, Norway
09:35 – 09:50 (NY)
15:35 − 15:50 (CET)
15:35 − 15:50 (CET)
A single short reprogramming early in life improves body fitness and increases lifespan in old age
Jean-Marc Lemaitre, Co-founder and co-director of the Institute of Regenerative Medicine and Biotherapies of Montpellier, France
09:50 – 10:00 (NY)
15:50 − 16:00 (CET)
15:50 − 16:00 (CET)
Break
10:00 – 10:20 (NY)
16:00 − 16:20 (CET)
16:00 − 16:20 (CET)
PandaOmics as a tool for omics research and target identification
Ivan Ozerov, Insilico Medicine, Hong Kong + Andrea Olsen, High School student, PandaOmics Case Study
10:20 – 10:40 (NY)
16:20 − 16:40 (CET)
16:20 − 16:40 (CET)
Mechanisms of brain aging and rejuvenation
Anne Brunet, Stanford, USA
10:40 – 11:00 (NY)
16:40 − 17:00 (CET)
16:40 − 17:00 (CET)
Clinical Application of Biological Clocks
Dina Radenkovic, Hooke London by Health and Longevity Optimisation, UK
11:00 – 11:20 (NY)
17:00 − 17:20 (CET)
17:00 − 17:20 (CET)
Break
11:20 – 11:40 (NY)
17:20 − 17:40 (CET)
17:20 − 17:40 (CET)
Aging of the hematopoietic stem cell niche
Maria Carolina Florian, Program for Regenerative Medicine, IDIBELL, Barcelona, Spain
11:40 – 12:00 (NY)
17:40 − 18:00 (CET)
17:40 − 18:00 (CET)
Diet and exercise: Pathways to stem cell rejuvenation
Thomas Rando, Stanford, USA
12:00 – 12:20 (NY)
18:00 − 18:20 (CET)
18:00 − 18:20 (CET)
BioAge: Building a pipeline of clinical-stage therapies that target the molecular causes of aging
Kristen Fortney, BioAge Labs, Inc., USA
12:20 – 13:00 (NY)
18:20 − 19:00 (CET)
18:20 − 19:00 (CET)
Break
13:00 – 14:00 (NY)
19:00 − 20:00 (CET)
19:00 − 20:00 (CET)
VC panel
Lisa Melton, Nature Biotech - Moderator
Michael Antonov, Formic Ventures; Maria Konovalenko, Formic Ventures;
Sergei Jakimov, LongeVC; Alexandra Bause, Apollo Ventures; Michael Greve, Kizoo Ventures; Daniel Schieferdecker, LongeVC; Anastasia Georgievskaya, Haut.ai; Paul Kholhaas, Molecule.to; Michelle Keller, Deep Longevity
Sergei Jakimov, LongeVC; Alexandra Bause, Apollo Ventures; Michael Greve, Kizoo Ventures; Daniel Schieferdecker, LongeVC; Anastasia Georgievskaya, Haut.ai; Paul Kholhaas, Molecule.to; Michelle Keller, Deep Longevity
14:00 – 15:00 (NY)
20:00 − 21:00 (CET)
20:00 − 21:00 (CET)
Poster session
Thursday, September 2
04:00 – 04:45 (NY)
10:00 − 10:45 (CET)
10:00 − 10:45 (CET)
Registrations, coffee, tea
04:45 – 05:00 (NY)
10:45 − 11:00 (CET)
10:45 − 11:00 (CET)
Welcome!
05:00 – 05:20 (NY)
11:00 − 11:20 (CET)
11:00 − 11:20 (CET)
DNA damage induced transcription stress and its connection with aging and neurodegeneration and the impact of nutrition
Jan Hoeijmakers, Erasmus Medical Center Rotterdam, Netherlands
05:20 – 05:40 (NY)
11:20 − 11:40 (CET)
11:20 − 11:40 (CET)
The path to longer lifespan and healthspan: smooth or bumpy?
Brian Kennedy, National University of Singapore, Singapore
05:40 – 06:00 (NY)
11:40 − 12:00 (CET)
11:40 − 12:00 (CET)
Characterization of a new premature aging disorder
Daniela Bakula, University of Copenhagen, Denmark
12:00 − 13:30 (CET)
Lunch
07:30 – 07:50 (NY)
13:30 − 13:50 (CET)
13:30 − 13:50 (CET)
Somatic mutations, genome mosaicism and aging
Jan Vijg, Albert Einstein College of Medicine, USA
07:50 – 08:10 (NY)
13:50 − 14:10 (CET)
13:50 − 14:10 (CET)
Genome maintenance mechanisms in aging
Björn Schumacher , University of Cologne, Germany
08:10 – 08:30 (NY)
14:10 − 14:30 (CET)
14:10 − 14:30 (CET)
Mechanisms of Longevity: from naked mole rat to bowhead whale
Vera Gorbunova, University of Rochester, USA
08:30 – 08:50 (NY)
14:30 − 14:50 (CET)
14:30 − 14:50 (CET)
Break
08:50 – 09:05 (NY)
14:50 − 15:05 (CET)
14:50 − 15:05 (CET)
Mitochondria enhancement enables late life dietary restriction to improve stem cells and lifespan
Karl Lenhard Rudolph, Research Group on Stem Cell Aging, Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)
09:05 – 09:20 (NY)
15:05 − 15:20 (CET)
15:05 − 15:20 (CET)
Mechanism of healthspan and lifespan extension by fumagillin derivatives
Michael R. MacArthur, Postdoctoral Fellow, Laboratory of Healthy Aging, Department of Health Sciences and Technology, ETH Zurich
09:20 – 09:35 (NY)
15:20 − 15:35 (CET)
15:20 − 15:35 (CET)
The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging
Suzanne Angeli, Buck Institute for Research on Aging, Novato, California, USA
09:35 – 09:50 (NY)
15:35 − 15:50 (CET)
15:35 − 15:50 (CET)
Dietary restriction prevents cell-intrinsic DNA damage driven neurotoxicity in neuron-specific DNA repair-deficient mouse mutants
Maria B. Birkisdottir, Department of Molecular Genetics and in the Department of Neuroscience of Erasmus MC, Netherlands
09:50 – 10:00 (NY)
15:50 − 16:00 (CET)
15:50 − 16:00 (CET)
Break
10:00 – 10:20 (NY)
16:00 − 16:20 (CET)
16:00 − 16:20 (CET)
Automated animal phenotyping at scale: Tracked.bio
Michael Petr, University of Copehagen, Tracked.bio
10:20 – 10:40 (NY)
16:20 − 16:40 (CET)
16:20 − 16:40 (CET)
Two conserved epigenetic regulators prevent healthy ageing
Shiqing Cai, Institute of Neuroscience, China
10:40 – 11:00 (NY)
16:40 − 17:00 (CET)
16:40 − 17:00 (CET)
Loss of skeletal muscle with aging and the adaptability to training — is it ever too late?
Michael Kjaer, University of Copenhagen, Denmark
11:00 – 11:20 (NY)
17:00 − 17:20 (CET)
17:00 − 17:20 (CET)
Break
11:20 – 11:40 (NY)
17:20 − 17:40 (CET)
17:20 − 17:40 (CET)
CNS-dependent control of integrated physiology
Jens Brüning, Max Planck Institute for Metabolism Research, Germany
11:40 – 12:00 (NY)
17:40 − 18:00 (CET)
17:40 − 18:00 (CET)
Fasting Mimicking Diet and Cancer Treatment
Valter Longo, USC Davis School of Gerontology, USA
12:00 – 12:20 (NY)
18:00 − 18:20 (CET)
18:00 − 18:20 (CET)
Building Cardiometabolic Resilience
Pam Taub, University of California San Diego School of Medicine, USA
12:20 – 13:00 (NY)
18:20 − 19:00 (CET)
18:20 − 19:00 (CET)
Break
13:00 – 13:20 (NY)
19:00 − 19:20 (CET)
19:00 − 19:20 (CET)
Modulation of longevity pathways via PP2A reduces senescence markers and promotes skin rejuvenation
Alessandra Zonari, CSO, OneSkin, USA
13:20 – 13:40 (NY)
19:20 − 19:40 (CET)
19:20 − 19:40 (CET)
Introduction to the DunedinPoAm Algorithm
Ryan Smith, Vice President of Business Development, TruDiagnostic
13:40 – 14:00 (NY)
19:40 − 20:00 (CET)
19:40 − 20:00 (CET)
Potential aging effects on the response to SARS-COV2
David Glass, Regeneron, USA
14:00 – 14:20 (NY)
20:00 − 20:20 (CET)
20:00 − 20:20 (CET)
Break
14:20 – 14:40 (NY)
20:20 − 20:40 (CET)
20:20 − 20:40 (CET)
Boosting NAD to promote metabolic health and healthy aging
Riekelt Houtkooper, Amsterdam UMC, Netherlands
14:40 – 15:00 (NY)
20:40 − 21:00 (CET)
20:40 − 21:00 (CET)
A salicylic acid derivative prevents Oxidative Damage in Skin
Sibylle Jäger, Scientific Manager, L'OREAL Research & Innovation
15:00 – 15:20 (NY)
21:00 − 21:20 (CET)
21:00 − 21:20 (CET)
New biotechnologies to address aging and disease: an overview
Kris Verburgh, Venture Partner Longevity Vision Fund
Friday, September 3
04:00 – 04:45 (NY)
10:00 − 10:45 (CET)
10:00 − 10:45 (CET)
Registrations, coffee, tea
04:45 – 05:00 (NY)
10:45 − 11:00 (CET)
10:45 − 11:00 (CET)
Welcome!
05:00 – 05:20 (NY)
11:00 − 11:20 (CET)
11:00 − 11:20 (CET)
Caloric restriction mimetics: antiaging agents that stimulate cancer immunosurveillance
Guido Kroemer, Université de Paris, France
05:20 – 05:40 (NY)
11:20 − 11:40 (CET)
11:20 − 11:40 (CET)
Embryogenesis Homeostasis and Aging
Gerard Karsenty, Columbia University, USA
05:40 – 06:00 (NY)
11:40 − 12:00 (CET)
11:40 − 12:00 (CET)
Artificial Intelligence Confirming Rejuvenation Treatment Success: The Role of Gender-Specific Scales In the Performance Evaluation
Anastasia Georgievskaya, Haut.AI, Estonia
12:00 − 13:30 (CET)
Lunch
07:30 – 07:50 (NY)
13:30 − 13:50 (CET)
13:30 − 13:50 (CET)
In vivo pooled screening – A scalable tool to unravel the complexity of aging and age-related disease
Martin Borch Jensen, Gordian Biotechnology, USA
07:50 – 08:10 (NY)
13:50 − 14:10 (CET)
13:50 − 14:10 (CET)
Gerotherapeutics from genetic based discovery in centenarians
Nir Barzilai, Albert Einstein College of Medicine, USA
08:10 – 08:30 (NY)
14:10 − 14:30 (CET)
14:10 − 14:30 (CET)
The Applications of Deep Aging Clocks in the Pharmaceutical Industry, Life Insurance, and Longevity Medicine
Alex Zhavoronkov, Insilico Medicine, Hong Kong
08:30 – 08:50 (NY)
14:30 − 14:50 (CET)
14:30 − 14:50 (CET)
Break
08:50 – 09:05 (NY)
14:50 − 15:05 (CET)
14:50 − 15:05 (CET)
Profiling epigenetic age in single cells
Alex Trapp, Harvard Medical School, USA
09:05 – 09:20 (NY)
15:05 − 15:20 (CET)
15:05 − 15:20 (CET)
Microfluidic-based device for fully automated aging studies in Caenorhabditis elegans
David Liaskos, The École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
09:20 – 09:35 (NY)
15:20 − 15:35 (CET)
15:20 − 15:35 (CET)
Biological age prediction from wearable device movement data identifies Nutritional and Pharmacological interventions for Healthy Aging
Georges Janssens, Amsterdam UMC, Netherlands
09:35 – 09:50 (NY)
15:35 − 15:50 (CET)
15:35 − 15:50 (CET)
Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice
Adam Freund, Arda Therapeutics
09:50 – 10:00 (NY)
15:50 − 16:00 (CET)
15:50 − 16:00 (CET)
Break
10:00 – 10:20 (NY)
16:00 − 16:20 (CET)
16:00 − 16:20 (CET)
SLC25A51 controls mitochondrial NAD levels
Joseph A. Baur, University of Pennsylvania, USA
10:20 – 10:40 (NY)
16:20 − 16:40 (CET)
16:20 − 16:40 (CET)
NAD metabolism and aging
Eric Verdin, Buck Institute, USA
10:40 – 11:00 (NY)
16:40 − 17:00 (CET)
16:40 − 17:00 (CET)
Recent Advances with Nicotinamide Riboside in Orphan Diseases and Aging
Frank Jaksch, Co-Founder & Executive Chairman, ChromaDex Corp.
11:00 – 11:20 (NY)
17:00 − 17:20 (CET)
17:00 − 17:20 (CET)
Break
11:20 – 11:40 (NY)
17:20 − 17:40 (CET)
17:20 − 17:40 (CET)
A Diversified Approach to Unlocking Geroprotector Development
James Peyer, Cambrian Biopharma, USA
11:40 – 12:00 (NY)
17:40 − 18:00 (CET)
17:40 − 18:00 (CET)
VitaDAO: Decentralising Longevity Research
Tyler Golato, CSO of Molecule, Switzerland
12:00 – 12:20 (NY)
18:00 − 18:20 (CET)
18:00 − 18:20 (CET)
Aging and protein homeostasis: lessons from progeria
Abigail Buchwalter, Assistant Professor, Cardiovascular Research Institute at the University of California, San Francisco
12:20 – 13:00 (NY)
18:20 − 19:00 (CET)
18:20 − 19:00 (CET)
Break
13:00 – 13:20 (NY)
19:00 − 19:20 (CET)
19:00 − 19:20 (CET)
Novel approaches to delay and reverse aging
David A. Sinclair, Co-Director of the Paul F. Glenn Center for Biology of Aging Research, honorary Professor at the University of Sydney, and co-founder of the journal Aging
13:20 – 13:40 (NY)
19:20 − 19:40 (CET)
19:20 − 19:40 (CET)
Epigenetic Markers for Human Health Assessments
Brian Chen, FOXO Technologies, USA
13:40 – 14:00 (NY)
19:40 − 20:00 (CET)
19:40 − 20:00 (CET)
Ageing: a gut feeling
Linda Partridge, Founding Director of the Max Planck Institute for Biology of Ageing in Cologne, Germany