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Program ARDD 2020
Tuesday, September 1
07:40 – 07:50 (NY)
13:40 − 13:50 (CET)
13:40 − 13:50 (CET)
Virtual Welcome!
Morten Scheibye-Knudsen, University of Copenhagen, Denmark
07:50 – 08:10 (NY)
13:50 − 14:10 (CET)
13:50 − 14:10 (CET)
Validating Interventions in Humans – Which approach is best
Brian Kennedy, National University of Singapore, Singapore
08:10 – 08:30 (NY)
14:10 − 14:30 (CET)
14:10 − 14:30 (CET)
Senotherapeutic compounds as a new class of molecules for prolonging skin health
Carolina Reis, OneSkin, USA
08:30 – 08:50 (NY)
14:30 − 14:50 (CET)
14:30 − 14:50 (CET)
Break
08:50 – 09:10 (NY)
14:50 − 15:10 (CET)
14:50 − 15:10 (CET)
AI and Longevity
Kai-Fu Lee, Sinovation Ventures and Sinovation AI Institute, China
09:10 – 09:30 (NY)
15:10 − 15:30 (CET)
15:10 − 15:30 (CET)
Longevity Pharmacology Comes of Age
João Pedro de Magalhães, University of Liverpool, UK
09:30 – 09:50 (NY)
15:30 − 15:50 (CET)
15:30 − 15:50 (CET)
"Age later" advise from those who do
Nir Barzilai, Albert Einstein College of Medicine, USA
09:50 – 10:00 (NY)
15:50 − 16:00 (CET)
15:50 − 16:00 (CET)
Break
10:00 – 10:20 (NY)
16:00 − 16:20 (CET)
16:00 − 16:20 (CET)
Towards better diagnostics and the pharmacological targeting of aging in humans
Christian Riedel, Karolinska, Sweden
10:20 – 10:40 (NY)
16:20 − 16:40 (CET)
16:20 − 16:40 (CET)
Predicting chronological age from hands images using neural networks
Anastasia Georgievskaya, Haut.AI, Estonia
10:40 – 11:00 (NY)
16:40 − 17:00 (CET)
16:40 − 17:00 (CET)
Can COVID-19 improve the medical incentives to develop longevity therapies?
Aubrey de Grey, AgeX, USA
11:00 – 11:20 (NY)
17:00 − 17:20 (CET)
17:00 − 17:20 (CET)
Break
11:20 – 11:40 (NY)
17:20 − 17:40 (CET)
17:20 − 17:40 (CET)
In vivo screening as a shortcut to anti-aging therapeutics
Martin Borch Jensen, Gordian Biotechnology, USA
11:40 – 12:00 (NY)
17:40 − 18:00 (CET)
17:40 − 18:00 (CET)
Deep Biomarkers of human aging
Polina Mamoshina, Deep Longevity, Hong Kong
12:00 – 12:20 (NY)
18:00 − 18:20 (CET)
18:00 − 18:20 (CET)
Of mice and men
Steve Horvath, University of California, Los Angeles, USA
12:20 – 13:00 (NY)
18:20 − 19:00 (CET)
18:20 − 19:00 (CET)
Break
13:00 – 14:00 (NY)
19:00 − 20:00 (CET)
19:00 − 20:00 (CET)
VC panel
Jim Mellon, Sergey Young, Wei-Wu He, Neal Bhadkamkar, Tyler Golato, Patrick Burgermeister, Alex Zhavoronkov, Kristen Fortney
Wednesday, September 2
Pre-program:
Live streamed
from UCPH
04:45–05:00 (NY)
10:45−11:00 (CET)
Live streamed
from UCPH
04:45–05:00 (NY)
10:45−11:00 (CET)
Pre-program Welcome!
Ulla Wewer, University of Copenhagen, Denmark
Pre-program:
Live streamed
from UCPH
05:00–05:30 (NY)
11:00−11:30 (CET)
Live streamed
from UCPH
05:00–05:30 (NY)
11:00−11:30 (CET)
Genetic networks regulate reproductive ageing and co-morbidities in humans
Eva Hoffmann, Center for Chromosome Stability, University of Copenhagen, Denmark
Pre-program:
Live streamed
from UCPH
05:30−06:00 (NY)
11:30−12:00 (CET)
Live streamed
from UCPH
05:30−06:00 (NY)
11:30−12:00 (CET)
Deep Visual Proteomics: Single cell sensitivity, deep learning, and clinical applications
Andreas Mund, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark
Pre-program:
Live streamed
from UCPH
06:00–06:30 (NY)
12:00−12:30 (CET)
Live streamed
from UCPH
06:00–06:30 (NY)
12:00−12:30 (CET)
Plasma biomarkers as indicators of dementia risk in population-based studies of dementia
Majken Jensen, Center for Healthy Aging, University of Copenhagen, Denmark
06:30−08:00 (NY)
12:30−14:00 (CET)
12:30−14:00 (CET)
Break
08:00–08:10 (NY)
14:00−14:10 (CET)
14:00−14:10 (CET)
Welcome!
Daniela Bakula, University of Copenhagen, Denmark
08:10–08:30 (NY)
14:10−14:30 (CET)
14:10−14:30 (CET)
The impact of DNA Damage and Nutrition on Aging and Neurodegeneration in Mice and Patients
Jan Hoeijmakers, Erasmus Medical Center Rotterdam, Netherlands
08:30–08:50 (NY)
14:30−14:50 (CET)
14:30−14:50 (CET)
To breathe or not to breathe: exploring how oxygen regulates senescence-associated phenotypes
Marсo Demaria, ERIBA, Netherlands
08:50−09:00 (NY)
14:50−15:00 (CET)
14:50−15:00 (CET)
Break
09:00–09:20 (NY)
15:00−15:20 (CET)
15:00−15:20 (CET)
Stochasticity in aging: pitfalls on the road to life extension
Jan Vijg, Albert Einstein College of Medicine, USA
09:20–09:40 (NY)
15:20−15:40 (CET)
15:20−15:40 (CET)
Targeting DNA repair for Aging Interventions
Morten Scheibye-Knudsen, University of Copenhagen, Denmark
09:40–10:00 (NY)
15:40−16:00 (CET)
15:40−16:00 (CET)
Heterogenity in Cellular Senescence and Development of Tailored Therapeutics
Peter de Keizer, University Medical Center Utrecht, Netherlands
10:00–10:20 (NY)
16:00−16:20 (CET)
16:00−16:20 (CET)
Break
10:20–10:30 (NY)
16:20−16:30 (CET)
16:20−16:30 (CET)
A novel small molecule inhibitor of IKK/NF-κB signaling reduces cellular senescence and improves health span in mouse models of accelerated and natural aging
Lei Zhang, University of Minnesota, USA
10:30–10:40 (NY)
16:30−16:40 (CET)
16:30−16:40 (CET)
Regulation of senescence by SenomiR-340-5p
Kotb Abdelmohsen, NIA - NIH, USA
10:40–10:50 (NY)
16:40−16:50 (CET)
16:40−16:50 (CET)
SIRT6 roles in DNA repair and neurodegeneration
Debra Toiber, Ben Gurion University of the Negev, Israel
10:50–11:00 (NY)
16:50−17:00 (CET)
16:50−17:00 (CET)
Integrating Scientific Solutions for Human Longevity and Performance
Wei-Wu He, Human Longevity Inc., USA
11:00–11:20 (NY)
17:00−17:20 (CET)
17:00−17:20 (CET)
Break
11:20–11:40 (NY)
17:20−17:40 (CET)
17:20−17:40 (CET)
Quantifying and manipulating the aging process
Vadim Gladyshev, Harvard, USA
11:40–12:00 (NY)
17:40−18:00 (CET)
17:40−18:00 (CET)
Molecular mechanisms linking epigenetic changes to longevity
Carlos Silva Garcia, Harvard, USA
12:00–12:20 (NY)
18:00−18:20 (CET)
18:00−18:20 (CET)
Studying the mechanisms of longevity of drosophila melanogaster
Alexey Moskalev, Russian Academy of Sciences, Russia
12:20–13:00 (NY)
18:20−19:00 (CET)
18:20−19:00 (CET)
Break
13:00–13:20 (NY)
19:00−19:20 (CET)
19:00−19:20 (CET)
NAD+ metabolism as a link between senescence and metabolic impairment during aging
Eric Verdin, Buck University, USA
13:20–13:40 (NY)
19:20−19:40 (CET)
19:20−19:40 (CET)
Lifestyle strategies for cardiometabolic disease
Pam Taub, UC San Diego, USA
13:40–14:00 (NY)
19:40−20:00 (CET)
19:40−20:00 (CET)
Exercise: Toward Therapeutics for Cellular Rejuvenation
Thomas Rando, Stanford, USA
Thursday, September 3
Pre-program:
Live streamed
from UCPH
05:00–05:30 (NY)
11:00−11:30 (CET)
Live streamed
from UCPH
05:00–05:30 (NY)
11:00−11:30 (CET)
Disease trajectories in a life long perspective
Søren Brunak, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark
Pre-program:
Live streamed
from UCPH
05:30–06:00 (NY)
11:30−12:00 (CET)
Live streamed
from UCPH
05:30–06:00 (NY)
11:30−12:00 (CET)
Metabolic control of DNA repair in age-related diseases
Lene Juel Rasmussen, Center for Healthy Aging, University of Copenhagen, Denmark
Pre-program:
Live streamed
from UCPH
06:00–06:30 (NY)
12:00−12:30 (CET)
Live streamed
from UCPH
06:00–06:30 (NY)
12:00−12:30 (CET)
Targeting skeletal stem cells for treatment of age-related osteoporosis
Moustapha Kassem, Molecular Endocrinology Unit, University of Southern Denmark, Denmark
06:30–08:00 (NY)
12:30−14:00 (CET)
12:30−14:00 (CET)
Break
08:00–08:10 (NY)
14:00−14:10 (CET)
14:00−14:10 (CET)
Welcome!
Morten Scheibye-Knudsen, University of Copenhagen, Denmark
08:10–08:30 (NY)
14:10−14:30 (CET)
14:10−14:30 (CET)
Genome Stability in Aging and Disease: New Perspectives from C. elegans
Björn Schumacher, University of Cologne, Germany
08:30–08:50 (NY)
14:30−14:50 (CET)
14:30−14:50 (CET)
mTOR longevity via integrated stress response and hydrogen sulphide signaling
Collin Ewald, ETH Zurich, Switzerland
08:50–09:00 (NY)
14:50−15:00 (CET)
14:50−15:00 (CET)
Break
09:00–09:20 (NY)
15:00−15:20 (CET)
15:00−15:20 (CET)
Molecular Mechanisms of Mitophagy and NAD+ in Brain Aging and Healthy Longevity
Evandro Fei Fang, University of Oslo, Norway
09:20–09:40 (NY)
15:20−15:40 (CET)
15:20−15:40 (CET)
Loss of CD38 exacerbates premature ageing in Cockayne Syndrome
Brenna Osborne, University of Copenhagen, Denmark
09:40–10:00 (NY)
15:40−16:00 (CET)
15:40−16:00 (CET)
Tweaking microbial metabolism with drugs to improve aging
Filipe Cabreiro, Imperial College London, UK
10:00–10:20 (NY)
16:00−16:20 (CET)
16:00−16:20 (CET)
Break
10:20–10:30 (NY)
16:20−16:30 (CET)
16:20−16:30 (CET)
The novel uncharacterized gene MYTHO controls autophagy and longevity
Anais Franco Romero, University of Padova, Italy
10:30–10:40 (NY)
16:30−16:40 (CET)
16:30−16:40 (CET)
Fasting, Not Calories, Drives the Metabolic and Molecular Response to a Calorie Restricted Diet
Heidi Pak, University of Wisconsin, USA
10:40–10:50 (NY)
16:40−16:50 (CET)
16:40−16:50 (CET)
Impaired lysosomal acidification triggers brain inflammation, preceding age-related demise
Nuno Raimundo, Universitätsmedizin Göttingen, Germany
10:50–11:00 (NY)
16:50−17:00 (CET)
16:50−17:00 (CET)
Urolithin A, a novel cellular nutrient to revitalize mitochondrial health and improve muscle strength
Pénélope Andreux, Amazentis, Switzerland
11:00–11:20 (NY)
17:00−17:20 (CET)
17:00−17:20 (CET)
Break
11:20–11:40 (NY)
17:20−17:40 (CET)
17:20−17:40 (CET)
Targeting of selective autophagy in aging and age-related disorders
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
11:40–12:00 (NY)
17:40−18:00 (CET)
17:40−18:00 (CET)
Targeting Healthspan: Functional Genetic Variation in Human Aging and Longevity
Yousin Suh, Columbia University, USA
12:00–12:20 (NY)
18:00 − 18:20 (CET)
18:00 − 18:20 (CET)
Mitochondrial dysfunction drives aging
Luigi Ferruci, National Institute on Aging - NIH, USA
12:20–13:00 (NY)
18:20−19:00 (CET)
18:20−19:00 (CET)
Break
13:00–13:20 (NY)
19:00−19:20 (CET)
19:00−19:20 (CET)
African killifishes shed light on evolution and modulation of vertebrate lifespan
Dario Valenzano, MPI Cologne, Germany
13:20–13:40 (NY)
19:20−19:40 (CET)
19:20−19:40 (CET)
Disulfiram treatment normalizes body weight in obese mice
Rafael de Cabo, NIA-NIH, USA
13:40–14:00 (NY)
19:40−20:00 (CET)
19:40−20:00 (CET)
Senolytic drugs: Finding the right target(s)
Judith Campisi, Buck Institute, USA
Friday, September 4
Pre-program:
Live streamed
from UCPH
05:00–05:50 (NY)
11:00−11:30 (CET)
Live streamed
from UCPH
05:00–05:50 (NY)
11:00−11:30 (CET)
Role of Nampt and NAD+ for skeletal muscle integrity and function
Jonas Thue Treebak, Novo Nordisk Foundation Center for Metabolic Research, University of Copenhagen, Denmark
Pre-program:
Live streamed
from UCPH
05:30–06:00 (NY)
11:30−12:00 (CET)
Live streamed
from UCPH
05:30–06:00 (NY)
11:30−12:00 (CET)
Contextualized Functions of Glycans in Human Tissue Formation
Ieva Bagdonaite, Center for Glycomics, University of Copenhagen, Denmark
Pre-program:
Live streamed
from UCPH
06:00–06:30 (NY)
12:00–12:30 (CET)
Live streamed
from UCPH
06:00–06:30 (NY)
12:00–12:30 (CET)
We have so much cerebrospinal fluid, but don't know how it is made
Nanna MacAuley, Department of Neuroscience, University of Copenhagen, Denmark
06:30–08:00 (NY)
12:30−14:00 (CET)
12:30−14:00 (CET)
Break
08:00 – 08:10 (NY)
14:00 − 14:10 (CET)
14:00 − 14:10 (CET)
Virtual Welcome!
Alex Zhavoronkov, Insilico Medicine, Hong Kong
08:10–08:30 (NY)
14:10−14:30 (CET)
14:10−14:30 (CET)
Reversal of cell senescence by resveralogues- from novel mechanisms to new therapies?
Richard Faragher, University of Brighton, UK
08:30–08:50 (NY)
14:30−14:50 (CET)
14:30−14:50 (CET)
Mitochondrial Form and Function in Longevity
Riekelt Houtkooper, Amsterdam UMC, Netherlands
08:50–09:00 (NY)
14:50−15:00 (CET)
14:50−15:00 (CET)
Break
09:00–09:20 (NY)
15:00−15:20 (CET)
15:00−15:20 (CET)
High SIRT6 activity correlates with longevity across animal species and in humans
Vera Gorbunova, University of Rochester, USA
09:20–09:40 (NY)
15:20−15:40 (CET)
15:20−15:40 (CET)
Flavonoids as senolytics
Laura Niedernhofer, University of Minnesota, USA
09:40–10:00 (NY)
15:40−16:00 (CET)
15:40−16:00 (CET)
Restricting dietary branched-chain amino acids promotes health and longevity in mice
Dudley Lamming, University of Wisconsin, USA
10:00–10:20 (NY)
16:00−16:20 (CET)
16:00−16:20 (CET)
Break
10:20–10:30 (NY)
16:20−16:30 (CET)
16:20−16:30 (CET)
Downregulation of the tyrosine degradation pathway, which is elevated with age and mitochondrial dysfunction, extends lifespan
Andrey Parkhitko, University of Pittsburgh, USA
10:30–10:40 (NY)
16:30−16:40 (CET)
16:30−16:40 (CET)
Age and life expectancy clocks based on machine learning analysis of mouse frailty
Alice Kane, Harvard, USA
10:40–10:50 (NY)
16:40 − 16:50 (CET)
16:40 − 16:50 (CET)
A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways
Marte Molenaars, Amsterdam UMC, Netherlands
10:50–11:00 (NY)
16:50 − 17:00 (CET)
16:50 − 17:00 (CET)
Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells
Adam Freund, Calico Life Sciences LLC, USA
11:00–11:20 (NY)
17:00 − 17:20 (CET)
17:00 − 17:20 (CET)
Break
11:20–11:40 (NY)
17:20 − 17:40 (CET)
17:20 − 17:40 (CET)
Molecular mechanisms of Aging
David Glass, Regeneron, USA
11:40–12:00 (NY)
17:40 − 18:00 (CET)
17:40 − 18:00 (CET)
From AI-Powered Drug Discovery to Longevity Medicine: a story of R&D and commercial innovation in longevity
Alex Zhavoronkov, Insilico Medicine, Hong Kong
12:00–12:20 (NY)
18:00 − 18:20 (CET)
18:00 − 18:20 (CET)
Juvenescence
Jim Mellon, Juvenescence, UK
12:20–13:00 (NY)
18:20 − 19:00 (CET)
18:20 − 19:00 (CET)
Break
13:00–13:20 (NY)
19:00 − 19:20 (CET)
19:00 − 19:20 (CET)
Regulation of muscle function by osteocalcin, implications for age-related decline in muscle function
Gerard Kersenty, Columbia University, USA
13:20–13:40 (NY)
19:20 − 19:40 (CET)
19:20 − 19:40 (CET)
Why Longevity is the Next Trillion Dollar Opportunity
Sergey Young, Longevity Vision Fund, USA
13:40–14:00 (NY)
19:40 − 20:00 (CET)
19:40 − 20:00 (CET)
Epigenetic reprogramming of aged tissues in vivo
David Sinclair, Harvard, USA