ARDD PROGRAM 2023
Longevity Medicine Day
Monday, August 28
08:00 - 09:00 (CET)
Coffee
09:00 - 09:20 (CET)
Opening ceremony
09:00 - 09:20 (CET)
Welcome of the organisers
Evelyne Bischof, MD, Chair of the Longevity Medicine Day
Renji Hospital, Shanghai; Jiaotong University; Sheba Longevity Center
Renji Hospital, Shanghai; Jiaotong University; Sheba Longevity Center
Nature Medicine - and longevity medicine
Michael Basson, Nature Medicine, USA
Welcome word to ARDD
Alex Zhavoronkov, PhD, Founder and CEO, Insilico Medicine
09:20 - 10:40 (CET)
Longevity medicine lectures: Interventions
Sponsored by Life Biosciences
Sponsored by Life Biosciences
Jerry McLaughlin, Chief Executive Officer, Life Biosciences, USA
Chair
Chair
Aging, Cellular Senescence, and Senolytics:
The Path to Translation
The Path to Translation
James Kirkland, MD, PhD, Noaber Foundation
Professor of Aging Research
Director, Robert and Arlene Kogod Center on Aging
Professor of Aging Research
Director, Robert and Arlene Kogod Center on Aging
Stem cell aging: From basic science to lifestyle interventions for rejuvenation
Thomas A. Rando, MD, PhD,Deputy Director, Stanford Center on Longevity
The Economics of Longevity
Michael Ringel, Managing Director and Senior Partner at BCG
Targeting aging with AI-based drug discovery
Alex Zhavoronkov, PhD, Founder and CEO, Insilico Medicine
10:40 - 10:45 (CET)
Coffee break
10:50 - 11:50 (CET)
From geroscience to gerotherapeutics
Nir Barzilai, Albert Einstein College of Medicine, USA
Longevity medicine therapeutics: applied geroprotective interventions, drug repurposing and discovery, RCTs
Joan Mannick, Co-Founder and CEO, Tornado Therapeutics
A Novel DNA Methylation Clock Resilient to Changes in Immune Composition
Eric Verdin, Buck Institute, USA
11:50 - 12:45 (CET)
Lunch and learn
Panel: Digital biomarker platfroms in longevity medicine
Rob Konrad, Biolytica, Switzerland
Nawal Roy, Founder and CEO of Holmusk, USA
12:45 - 13:45 (CET)
Longevity medicine lectures: clinical practice globally
Longevity Departments at a public hospital
Tzipora Strauss, MD, Chaim Sheba Medical Center, Tel Hashomer, Israel
Evidence based interventions to prolong health and lifespan in humans
Andrea B. Maier, Oon Chiew Seng Professor,
Co-Director Centre for Healthy Longevity, National University of Singapore; Professor of Gerontology, Vrije Universiteit Amsterdam
Co-Director Centre for Healthy Longevity, National University of Singapore; Professor of Gerontology, Vrije Universiteit Amsterdam
Healthy longevity medicine in the clinic - developing guidelines and educating physicians
Evelyne Bischof, MD, Chair of the Longevity Medicine Day
Renji Hospital, Shanghai; Jiaotong University; Sheba Longevity Center
Renji Hospital, Shanghai; Jiaotong University; Sheba Longevity Center
13:45 - 14:00 (CET)
Coffee break
14:00 - 16:00 (CET)
Longevity medicine lectures: Clinical trials and translational science in mental and behavioral health
Challenges in Behavioral Health, Longevity Medicine and Clinical and Translational Science
Harold Pincus, Columbia University, USA
Senolytics - lessons from clinical trials from brain tumors
Li Wenbin, Beijing Tiantan Hospital, China
Longevity in People with Severe Mental Illness: Adding Years to Life and Life to Years
Prof. Christoph Correll, Charité University Medicine, Germany
A combination of metformin and galantamine exhibits synergistic benefits in the treatment of sarcopenia
Evi Mercken, Rejuvenate Biomed
16:00 - 16:15 (CET)
Coffee break
16:15 - 17:15 (CET)
The challenges of longevity medicine in primary care practice
Jordan Shlain, Founder, Exec. Chair of Private Medical, USA
Practical application of longevity science into a medical practice. Correlation of biological clocks, medical biomarkers and most effective interventions
Dariusz Sołdacki, Scientific Director at Longevity Center Europe, Poland
Genetic Basis of Aging and Physical Fitness in Healthy Longevity
Christine Huang, Hong Kong Quantum AI Lab and the University of Hong Kong
Longitudinal longevity data analysis - insights and lessons from a decade of Insidetrack-ing
Gil Blander, InsideTracker, USA
17:15 - 19:00 (CET)
Healthy Longevity Medicine (HLMS) session
Clinical cases in longevity medicine - presentation and discussion
Clinical cases in longevity medicine - presentation and discussion
Evelyne Bischof, MD, Chair of the Longevity Medicine Day
Renji Hospital, Shanghai; Jiaotong University; Sheba Longevity Center
Renji Hospital, Shanghai; Jiaotong University; Sheba Longevity Center
moderator
Andrea B. Maier, Oon Chiew Seng Professor,
Co-Director Centre for Healthy Longevity, National University of Singapore; Professor of Gerontology, Vrije Universiteit Amsterdam
Co-Director Centre for Healthy Longevity, National University of Singapore; Professor of Gerontology, Vrije Universiteit Amsterdam
moderator
19:00 (CET)
Synthesis of the Meeting, Take Home Message and the Big Questions.
Evelyne Bischof, MD, Chair of the Longevity Medicine Day
Renji Hospital, Shanghai; Jiaotong University; Sheba Longevity Center
Renji Hospital, Shanghai; Jiaotong University; Sheba Longevity Center
19:05 - 20:00 (CET)
Dinner
20:00 - 02:00 (CET)
Drinks and socializing at Bar7
Emerging Science
& Technologies Workshop
& Technologies Workshop
Monday, August 28
09:00 - 09:10 (CET)
Opening of the Workshop
Maximilian Unfried
09:10 - 10:20 (CET)
Session 1:
Advancing Biological Techniques to develop better rejuvenation therapies
Advancing Biological Techniques to develop better rejuvenation therapies
Spatial transcriptomics to reveal psychiatric mechanisms in space
Konstantin Khodosevich, Biotech Research & Innovation Centre, University of Copenhagen
Rational design approaches to the discovery of novel cryoprotectants
Alexandra Stolzing, Loughborough University, Centre for Biological Engineering, Loughborough, UK
DNA-encoded libraries to discover novel therapeutic molecules for age-related diseases
Eric Morgen, PhD, Co-founder BioAge Labs, USA
10:20 - 10:35 (CET)
Coffee break
10:35 - 11:45 (CET)
Session 2:
The opportunities and perils using Artificial Intelligence for Longevity Science
The opportunities and perils using Artificial Intelligence for Longevity Science
Longevity GPT: Large Language Models for Longevity
Anton Kulaga, Systems Biology of Aging Group, Romanian Academia an Just-DNA-Seq Open Source Project
Hybrid quantum-classical machine learning for generative chemistry and drug design
Peter Fedichev, CEO Gero, Singapore
Machine Learning in science and Medicine: Just a Toy?
Emily Sullivan, PhD, Department of Industrial Engineering & Innovation Sciences Eindhoven University of Technology
11:45 - 12:45 (CET)
Lunch
12:45 - 13:45 (CET)
Session 3:
Psychological and behavioral aspects of ageing
Psychological and behavioral aspects of ageing
Quantum Healthy Longevity: From Cells to Cities
Tina Woods, Founder & CEO, Collider Health
Buddhist Meditation for a Healthy Brain
Andrea Olsen, CEO of The Youth Longevity Association, UK
Potentials and pitfalls of psychedelic therapy
David Erritzoe, Deputy Head and Clinical Director of Centre for Psychedelic Research, Imperial College, UK
13:45 - 14:00 (CET)
Coffee break
14:00 - 15:15 (CET)
Session 4:
Accelerating Longevity Research through Decentralized Science
Accelerating Longevity Research through Decentralized Science
What is decentralize Science?
Max Unfried, National University of Singapore & VitaDAO
Reproductive Ageing in the Age of Decentralization
Maria Marinova, PhD, Dealflow Lead AthenaDAO
14:40 - 15:15 (CET)
DeSci Panel Discussion
Tim Peterson, BIOIO and VitaDAO
Eleanor Davies, Dealflow Steward, VitaDAO, Canada
Maria Marinova, AthenaDAO, Switzerland
15:15 - 15:30 (CET)
Break
15:30 - 17:00 (CET)
Session 5:
Hands on Breakout Sessions
Hands on Breakout Sessions
Breakout 1: How to start a company from the Lab 101
Sebastian Brunemeier, General Partner Healthspan Capital, USA
Eleanor Davies, Dealflow Steward, VitaDAO, Canada
Breakout 2: How to get started on the Blockchain
Estefano Pinilla, Aarhus University& VitaDAO
Paolo Binetti, VitaDAO
Breakout 3: Applying large language models to personal genomics and longevity
Anton Kulaga, Systems Biology of Aging Group, Romanian Academia an Just-DNA-Seq Open Source Project
Maria Koval, Just-DNA-Seq Open Source Project
Tuesday, August 29
02:00 - 03:00 AM (NY)
08:00 - 09:00 (CET)
08:00 - 09:00 (CET)
Registrations, coffee, tea
03:00 - 03:10 AM (NY)
9:00 - 9:10 (CET)
9:00 - 9:10 (CET)
Welcome!
Morten Scheibye-Knudsen, University of Copenhagen, Denmark
Daniela Bakula, University of Copenhagen, Denmark
Alex Zhavoronkov, Insilico Medicine, Hong Kong
03:10 - 03:30 AM (NY)
09:10 - 09:30 (CET)
09:10 - 09:30 (CET)
Epigenetic control of stem cell aging and rejuvenation
Thomas A. Rando, MD, PhD,Deputy Director, Stanford Center on Longevity
03:30 - 03:50 AM (NY)
09:30 - 09:50 (CET)
09:30 - 09:50 (CET)
Public Markets for IP: First Lessons Financing Longevity Research via Decentralised Science
Paul Kohlhaas, Co-Founder & CEO Molecule, Switzerland
03:50 - 04:10 AM (NY)
09:50 - 10:10 (CET)
09:50 - 10:10 (CET)
Geroncology and healthy longevity medicine - the crossroads, status quo and outlook
Prof. Evelyne Bischof, MD, Chair of the Longevity Medicine Day
Renji Hospital, Shanghai; Jiaotong University; Sheba Longevity Center
Renji Hospital, Shanghai; Jiaotong University; Sheba Longevity Center
04:10 - 04:30 AM (NY)
10:10 - 10:30 (CET)
10:10 - 10:30 (CET)
Coffee break
04:30 - 04:50 AM (NY)
10:30 - 10:50 (CET)
10:30 - 10:50 (CET)
Supplements to improve the function of physiological systems in humans.
Andrea Maier, NUS, Singapore
04:50 - 05:10 AM (NY)
10:50 - 11:10 (CET)
10:50 - 11:10 (CET)
The anti-inflammatory effects of exercise
Bente Klarlund Pedersen, Centre for Physical Activity Research, Rigshospitalet, Denmark
05:10 - 05:30 AM (NY)
11:10 - 11:30 (CET)
11:10 - 11:30 (CET)
Expanding the horizons of proteins in aging research: energetics and splicing variants!
Luigi Ferrucci, National Institute on Aging
05:30 - 07:00 AM (NY)
11:30 - 13:00 (CET)
11:30 - 13:00 (CET)
Lunch
07:00 - 07:20 AM (NY)
13:00 - 13:20 (CET)
13:00 - 13:20 (CET)
Autophagy's role in immune aging
Anna Katharina Simon, University of Oxford , UK
07:20 - 07:40 AM (NY)
13:20 - 13:40 (CET)
13:20 - 13:40 (CET)
All 'A's: Ageing, Alzheimer's disease, Autophagy, and Artificial Intelligence
Evandro Fang, University of Oslo, Norway
07:40 - 08:00 AM (NY)
13:40 - 14:00 (CET)
13:40 - 14:00 (CET)
Cellular aging and organelle connectivity
Sabrina Büttner, Stockholm University, Sweden
08:00 - 08:20 AM (NY)
14:00 - 14:20 (CET)
14:00 - 14:20 (CET)
Coffee break
08:20 - 08:40 AM (NY)
14:20 - 14:40 (CET)
14:20 - 14:40 (CET)
Extending Healthspan with a Synthetic Immune System
J. "Scotch" McClure, Founder, CEO & Chairman of Maxwell Biosciences
08:40 - 09:00 AM (NY)
14:40 - 15:00 (CET)
14:40 - 15:00 (CET)
Harnessing the Immune System to Eliminate Senescent Cells & Treat Diseases of Aging
Robin Mansukhani, Deciduous Therapeutics, USA
09:00 - 09:20 AM (NY)
15:00 - 15:20 (CET)
15:00 - 15:20 (CET)
The Aging Human Repeatome: Connections to Chronic Inflammation
John Sedivy, Brown University, USA
09:20 - 10:00 AM (NY)
15:20 - 16:00 (CET)
15:20 - 16:00 (CET)
Poster Session
10:00 - 10:20 AM (NY)
16:00 - 16:20 (CET)
16:00 - 16:20 (CET)
The plasma proteome as sensor of organ physiology and aging
Tony Wyss-Coray , Stanford University, USA
10:20 - 10:40 AM (NY)
16:20 - 16:40 (CET)
16:20 - 16:40 (CET)
3 ideas for better longevity
Rob Konrad , Biolytica, Switzerland
10:40 - 11:00 AM (NY)
16:40 - 17:00 (CET)
16:40 - 17:00 (CET)
Immune-metabolic mechanisms of cognitive decline in aging
Katrin Andreasson , Stanford University, USA
11:00 - 11:20 AM (NY)
17:00 - 17:20 (CET)
17:00 - 17:20 (CET)
Coffee break
11:20 - 11:40 AM (NY)
17:20 - 17:40 (CET)
17:20 - 17:40 (CET)
Developing OMICmAge, a multi-omics informed biological age clock
Varun Dwaraka , TruDiagnostic, USA
11:40 - 12:00 AM (NY)
17:40 - 18:00 (CET)
17:40 - 18:00 (CET)
Mitochondrial regulation of stem cell aging
Danica Chen , University of California, Berkeley, USA
12:00 - 12:20 PM (NY)
18:00 - 18:20 (CET)
18:00 - 18:20 (CET)
Developing small molecule therapy targeting the hallmarks of aging
Toren Finkel , University of Pittsburgh School of Medicine, USA
12:20 - 01:00 PM (NY)
18:20 - 19:00 (CET)
18:20 - 19:00 (CET)
Dinner
01:00 - 01:20 PM (NY)
19:00 - 19:20 (CET)
19:00 - 19:20 (CET)
Tales of the molecular garbageman
Kelsey Moody , Ichor Life Sciences, Inc., USA
01:20 - 01:40 PM (NY)
19:20 - 19:40 (CET)
19:20 - 19:40 (CET)
Epigenetic reprogramming- A novel gene therapy that restores visual function in a nonhuman primate model of NAION
Sharon Rosenzweig-Lipson , Life Biosciences, USA
01:40 - 02:00 PM (NY)
19:40 - 20:00 (CET)
19:40 - 20:00 (CET)
Mechanisms of brain aging and rejuvenation
Anne Brunet, Stanford University, USA
02:00 - 02:10 PM (NY)
20:00 - 20:10 (CET)
20:00 - 20:10 (CET)
2 years into longevity investing - approach and challenges
Sergey Jakimov , founding partner of LongeVC, Switzerland
02:10 - 03:00 PM (NY)
20:10 - 21:00 (CET)
20:10 - 21:00 (CET)
VC panel
Lisa Melton, Nature Biotechnology
Moderator
Moderator
Evelyne Bischof, Sheba Longevity Center, co-author of Investing in Longevity 101 Course
Michael Ringel, BCG
Garri Zmudze, LongeVC
Asif Bhatti, America's Frontier Fund
James Peyer, Cambrian
Anastasia Georgievskaya, Haut.AI
03:00 - 08:00 PM (NY)
21:00 - 02:00 (CET)
21:00 - 02:00 (CET)
Drinks and socializing at Bar7
Wednesday, August 30
02:00 - 03:00 AM (NY)
08:00 - 09:00 (CET)
08:00 - 09:00 (CET)
Registrations, coffee, tea
03:00 - 03:10 AM (NY)
09:00 - 09:10 (CET)
09:00 - 09:10 (CET)
Welcome!
03:10 - 03:30 AM (NY)
09:10 - 09:30 (CET)
09:10 - 09:30 (CET)
A tale of old and new love: Insights into longevity and rejuvenation from diapause
Adam Antebi , Max Planck Institute for Biology of Ageing, Germany
03:30 - 03:50 AM (NY)
09:30 - 09:50 (CET)
09:30 - 09:50 (CET)
Poor old Pores; Surveillance of the intrinsically disordered FG-nucleoporins
Liesbeth Veenhoff , University Medical Center Groningen, The Netherlands
03:50 - 04:10 AM (NY)
09:50 - 10:10 (CET)
09:50 - 10:10 (CET)
Do longevity interventions repair age-related collagen crosslinking?
Collin Ewald , ETH Zurich, Switzerland
04:10 - 04:30 AM (NY)
10:10 - 10:30 (CET)
10:10 - 10:30 (CET)
Break
04:30 - 04:50 AM (NY)
10:30 - 10:50 (CET)
10:30 - 10:50 (CET)
Cellular Senescence and Human Longevity
Yousin Suh, Columbia University, USA
04:50 - 05:10 AM (NY)
10:50 - 11:10 (CET)
10:50 - 11:10 (CET)
Proactive clinical monitoring of immune system aging
Natalia Mitin, CEO and Co-Founder, Sapere Bio
05:10 - 05:30 AM (NY)
11:10 - 11:30 (CET)
11:10 - 11:30 (CET)
Activation of GNAQ rejuvenates memory in aged animals
Coleen Murphy, Princeton University, USA
05:30 - 07:00 AM (NY)
11:30 - 13:00 (CET)
11:30 - 13:00 (CET)
Lunch
07:00 - 07:20 AM (NY)
13:00 - 13:20 (CET)
13:00 - 13:20 (CET)
Genome Stability in Aging and Disease: New insights and therapeutic avenues
Björn Schumacher, University of Cologne, Germany
07:20 - 07:40 AM(NY)
13:20 - 13:40 (CET)
13:20 - 13:40 (CET)
Developing gerotherapeutics by defining mechanisms of action (MoAs)
Tim Peterson, BIOIO and VitaDAO
07:40 - 08:00 (NY)
13:40 - 14:00 (CET)
13:40 - 14:00 (CET)
Genome instability, aging and disease
Jan Vijg , Albert Einstein College of Medicine, USA
08:00 - 08:20 (NY)
14:00 - 14:20 (CET)
14:00 - 14:20 (CET)
Coffee break
08:20 - 08:35 AM (NY)
14:20 - 14:35 (CET)
14:20 - 14:35 (CET)
Accurate aging clocks based on accumulating stochastic variation
David Meyer, University of Cologne, Germany
08:35 - 08:50 AM (NY)
14:35 - 14:50 (CET)
14:35 - 14:50 (CET)
Promoting Longevity through Circadian Clock-Oriented Feeding
Victoria Acosta Rodriguez
08:50 - 09:05 AM (NY)
14:50 - 15:05 (CET)
14:50 - 15:05 (CET)
Causal Epigenetic Age Uncouples Damage and Adaptation
Kejun Albert Ying, Harvard Medical School, USA
09:05 - 09:20 (NY)
15:05 - 15:20 (CET)
15:05 - 15:20 (CET)
Why fast glycolytic muscle decline first during ageing
Fabian Finger, Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen
09:20 - 10:00 (NY)
15:20 - 16:00 (CET)
15:20 - 16:00 (CET)
Poster session
10:00 - 10:20 AM (NY)
16:00 - 16:20 (CET)
16:00 - 16:20 (CET)
The neuro-vascular interface in cardiac ageing
Stefanie Dimmeler , Goethe-University Frankfurt, Germany
10:20 - 10:40 AM (NY)
16:20 - 16:40 (CET)
16:20 - 16:40 (CET)
Clearance of Intracellular Free Cholesterol by Liver-Targeted LNP-mRNA Therapy Reverses Cardiovascular and Metabolic Disease
Mourad Topors , Repair Biotechnologies, USA
10:40 - 11:00 AM (NY)
16:40 - 17:00 (CET)
16:40 - 17:00 (CET)
Inspire Longevity: Forging New Horizons
Andrea Olsen, CEO The Youth Longevity Association, UK
Jamie Justice, XPRIZE, USA
11:00 - 11:20 AM(NY)
17:00 - 17:20 (CET)
17:00 - 17:20 (CET)
Coffee break
11:20 - 11:40 AM (NY)
17:20 - 17:40 (CET)
17:20 - 17:40 (CET)
Pharma.AI: Commercially-available AI-Platform with Reinforcement Learning from Expert Human and Experimental Feedback for Acceleration of Drug Discovery and Aging Research
Petrina Kamya, Insilico Medicine, Canada
Frank Pun, Insilico Medicine, Hong Kong
11:40 - 12:00 AM(NY)
17:40 - 18:00 (CET)
17:40 - 18:00 (CET)
Gut-liver axis in healthy ageing: microbiome modulates chronic liver disease in mice
Folkert Kuipers , University Medical Center Groningen, The Netherlands
12:00 - 12:20 PM (NY)
18:00 - 18:20 (CET)
18:00 - 18:20 (CET)
Epigenetic stabilization and reprogramming: an update
David Sinclair , Harvard Medical School, USA
12:20 - 01:00 PM (NY)
18:20 - 19:00 (CET)
18:20 - 19:00 (CET)
Dinner
01:00 PM (NY)
19:00 (CET)
19:00 (CET)
Gala Dinner (for speakers only)
01:00 - 02:00 PM (NY)
19:00 - 20:00 (CET)
19:00 - 20:00 (CET)
Poster session
02:00 - 08:00 PM (NY)
20:00 - 02:00 (CET)
20:00 - 02:00 (CET)
Drinks and socializing in Bar7
Thursday, August 31
02:00 - 03:00 AM (NY)
08:00 - 09:00 (CET)
08:00 - 09:00 (CET)
Registrations, coffee, tea
03:00 - 03:10 AM (NY)
09:00 − 09:10 (CET)
09:00 − 09:10 (CET)
Welcome!
03:10 - 03:30 AM (NY)
09:10 - 09:30 (CET)
09:10 - 09:30 (CET)
Evolution and Ecology of Aging
Dario Valenzano , Friedrich Schiller University of Jena, Germany
03:30 - 03:50 AM (NY)
09:30 - 09:50 (CET)
09:30 - 09:50 (CET)
Rejuveron: multifocal approach to tackle longevity
Gabor Gyülveszi, Rejuveron Life Sciences AG, Switzerland
03:50 - 04:10 AM (NY)
09:50 - 10:10 (CET)
09:50 - 10:10 (CET)
The Science and Clinical Application of Biological Age Estimation
Alexey Moskalev, George Mason University, USA
04:10 - 04:30 AM (NY)
10:10 - 10:30 (CET)
10:10 - 10:30 (CET)
Coffee break
04:30 - 04:50 AM (NY)
10:30 - 10:50 (CET)
10:30 - 10:50 (CET)
Genetics and epigenetics of the glycan clock for biological age
Aleksandar Vojta, GlycanAge, UK
04:50 - 05:10 AM (NY)
10:50 - 11:10 (CET)
10:50 - 11:10 (CET)
Cellular and Tissue Rejuvenation through Epigenetic Reprogramming
Vittorio Sebastiano, Turn Biotechnologies, USA
05:10 - 05:30 AM (NY)
11:10 - 11:30 (CET)
11:10 - 11:30 (CET)
Breaking Through Longevity Barriers
Boris Djordjevic, Chief Executive Officer 199 Biotechnologies, UK
05.30 - 07.00 AM (NY)
11:30 - 13:00 (CET)
11:30 - 13:00 (CET)
Lunch
07:00 - 07:20 AM (NY)
13:00 - 13:20 (CET)
13:00 - 13:20 (CET)
Mette Kierkgaard, Minister for Senior Citizens, Denmark
07:20 - 07:40 AM (NY)
13:20 - 13:40 (CET)
13:20 - 13:40 (CET)
Morten Scheibye-Knudsen, University of Copenhagen, Denmark
07:40 - 08:00 AM (NY)
13:40 - 14:00 (CET)
13:40 - 14:00 (CET)
Biomarkers for Human Longevity
Nir Barzilai, Albert Einstein College of Medicine, USA
08:00 - 08:20 AM (NY)
14:00 - 14:20 (CET)
14:00 - 14:20 (CET)
Coffee break
08:20 – 08:35 AM (NY)
14:20 − 14:35 (CET)
14:20 − 14:35 (CET)
Trigonelline is a novel NAD+ precursor with muscle longevity benefits across species
Vincenzo Sorrentino, Assistant Professor, National University of Singapore, Yong Loo Lin School of Medicine
08:35 – 08:50 AM (NY)
14:35 − 14:50 (CET)
14:35 − 14:50 (CET)
Promoting longevity using endogenous metabolites
Chieh Chen, UCLA, USA
08:50 – 09:05 AM (NY)
14:50 − 15:05 (CET)
14:50 − 15:05 (CET)
Evaluating the impact of putative drug targets of metformin on phenotypic age and leukocyte telomere length in the UK Biobank using genetics
Shan Luo, The University of Hong Kong, Hong Kong
09:05 – 09:20 AM (NY)
15:05 − 15:20 (CET)
15:05 − 15:20 (CET)
Taurine deficiency as a driver of aging
Parminder Singh, Buck Institute, USA
09:20 - 10:00 AM (NY)
15:20 - 16.00 (CET)
15:20 - 16.00 (CET)
Poster session
10:00 - 10:20 AM (NY)
16:00 - 16:20 (CET)
16:00 - 16:20 (CET)
Novel senotherapeutic approaches to extend healthspan
Paul Robbins, University of Minnesota, USA
10:20 - 10:40 AM (NY)
16:20 - 16:40 (CET)
16:20 - 16:40 (CET)
Muscle aging and healthy weight loss: From the BioAge discovery platform to clinical trials
Paul Rubin, BioAge Labs, Inc., USA
10:40 - 11:00 AM (NY)
16:40 - 17:00 (CET)
16:40 - 17:00 (CET)
Mechanical regulation of stem cell state and aging
Sara Wickström, Max Planck Institute for Molecular Biomedicine, Germany
11:00 - 11:20 AM (NY)
17:00 - 17:20 (CET)
17:00 - 17:20 (CET)
Coffee break
11:20 - 11:40 AM (NY)
17:20 - 17:40 (CET)
17:20 - 17:40 (CET)
Manipulating Mitochondrial NAD
Joe Baur, University of Pennsylvania, USA
11:40 - 12:00 AM (NY)
17:40 - 18:00 (CET)
17:40 - 18:00 (CET)
Stepping stones towards anti-ageing drug discovery
John Speakman, Shenzhen Institutes of Advanced Technology in Shenzhen, China
12:00 - 12:20 PM (NY)
18:00 - 18:20 (CET)
18:00 - 18:20 (CET)
Human immune aging
Eric Verdin, Buck Institute, USA
12:20 - 01:00 PM (NY)
18:20 - 19:00 (CET)
18:20 - 19:00 (CET)
Dinner
01:00 - 01:20 PM (NY)
19:00-19:20 (CET)
19:00-19:20 (CET)
The body and beyond: Therapeutic Opportunities Presented by Modulation of Cellular Senescence
Richard Faragher, University of Brighton, UK
01:20 - 01:40 PM (NY)
19:20 - 19:40 (CET)
19:20 - 19:40 (CET)
Therapeutic targeting of cellular senescence heterogeneity across age-related diseases
Marco Quarta, Rubedo Life Sciences, USA
01:40 - 02:00 PM (NY)
19:40 - 20:00 (CET)
19:40 - 20:00 (CET)
Pre-clinical models for testing geroprotectors
Laura Niedernhofer, University of Minnesota, USA
02:00 - 02:20 PM (NY)
20:00 - 20:20 (CET)
20:00 - 20:20 (CET)
Break
02:20 - 02:40 PM (NY)
20:20 - 20:40 (CET)
20:20 - 20:40 (CET)
Fasting Mimicking Diets, Multi-system regeneration and Longevity
Valter Longo, USC Davis School of Gerontology, USA
02:40 - 03:00 PM (NY)
20:40 - 21:00 (CET)
20:40 - 21:00 (CET)
Cambrian Bio – Bringing a pipeline to patients
James Peyer, Cambrian Biopharma, USA
03:00 - 03:20 PM (NY)
21:00 - 21:20 (CET)
21:00 - 21:20 (CET)
Predictions and Associations with Lifespan and Healthspan Outcomes in SLAM
Rafael de Cabo, National Institutes of Health, USA
03:20 - 08:00 PM (NY)
21:20 - 02:00 (CET)
21:20 - 02:00 (CET)
Drinks and socializing in Bar7
Friday, September 1
02:00 - 03:00 AM (NY)
08:00 - 09:00 (CET)
08:00 - 09:00 (CET)
Registrations, coffee, tea
03:00 - 03:15 AM (NY)
09:00 − 09:15 (CET)
09:00 − 09:15 (CET)
Welcome and Poster Award ceremony
03:15 - 03:35 AM (NY)
09:15 - 09:35 (CET)
09:15 - 09:35 (CET)
Maintaining epigenome fidelity across cell divisions – implications for aging
Anja Groth, University of Copenhagen, Denmark
03:35 - 03:55 AM (NY)
09:35 - 09:55 (CET)
09:35 - 09:55 (CET)
Molecular mechanisms of reproductive ageing
Eva Hoffmann, University of Copenhagen, Denmark
03:55 - 04:15 AM (NY)
09:55 - 10:15 (CET)
09:55 - 10:15 (CET)
Aging Research and Generative AI as a Platform for Pharmaceutical Drug Discovery: multi-modal multi-omics and multi-species transformer-based age generators for target and drug discovery
Alex Zhavoronkov, Insilico Medicine, Hong Kong
04:15 - 04:30 AM (NY)
10:15 - 10:30 (CET)
10:15 - 10:30 (CET)
Coffee break
04:30 - 04:50 AM (NY)
10:30 - 10:50 (CET)
10:30 - 10:50 (CET)
Understanding Protein Homeostasis – Improving Protein Metabolism and Reducing Sarcopenia
Shih-Yin Tsai, NUS, Singapore
04:50 - 05:10 AM (NY)
10:50 - 11:10 (CET)
10:50 - 11:10 (CET)
Aging clocks, entropy, and the limits of age-reversal
Peter Fedichev, Gero, Singapore
05:10 - 05:30 AM (NY)
11:10 - 11:30 (CET)
11:10 - 11:30 (CET)
CD38 as a target for age-related metabolic dysfunction: from basic science to translation
Eduardo Chini, Mayo Clinic, USA
05.30 - 07.00 AM (NY)
11:30 - 13:00 (CET)
11:30 - 13:00 (CET)
Lunch
07:00 - 07:20 AM (NY)
13:00 - 13:20 (CET)
13:00 - 13:20 (CET)
Transcriptomic and proteomic signatures of longevity
Vera Gorbunova, University of Rochester, USA
07:20 - 07:40 AM (NY)
13:20 - 13:40 (CET)
13:20 - 13:40 (CET)
Two years of Retro
Joe Betts-LaCroix, Retro Biosciences, USA
07:40 - 08:00 AM (NY)
13:40 - 14:00 (CET)
13:40 - 14:00 (CET)
The long and short of bats’ extended healthspans
Emma Teeling, Professor, University College Dublin, Ireland
08:00 - 08:20 AM (NY)
14:00 - 14:20 (CET)
14:00 - 14:20 (CET)
Coffee break
08:20 – 08:35 AM (NY)
14:20 − 14:35 (CET)
14:20 − 14:35 (CET)
Herbal terpenoids transiently dampen mitochondrial bioenergetics to activate autophagy and mitophagy and protect from metabolic stress and aging
Gabriele Civiletto, Nestlé Institute of Health Sciences, Switzerland
08:35 – 08:50 AM (NY)
14:35 − 14:50 (CET)
14:35 − 14:50 (CET)
Intracellular calcium mediates neuronal mitophagy upon stress
Konstantinos Palikaras, National and Kapodistrian University of Athens, Greece
08:50 – 09:05 AM (NY)
14:50 − 15:05 (CET)
14:50 − 15:05 (CET)
Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity
Roberto Ripa, Max Planck Institute, Germany
09:05 – 09:20 AM (NY)
15:05 − 15:20 (CET)
15:05 − 15:20 (CET)
Age-induced thiol oxidation predisposes brain for neurodegeneration via aberrant phase separation
Milos Filipovic, ISAS, Germany
09:20 - 10:00 AM (NY)
15:20 - 16.00 (CET)
15:20 - 16.00 (CET)
Coffee break
10:00 - 10:20 AM (NY)
16:00 - 16:20 (CET)
16:00 - 16:20 (CET)
Muscle stem cells in age and disease
Julia von Maltzahn, Fritz Lipmann Institute, Germany
10:20 - 10:40 AM (NY)
16:20 - 16:40 (CET)
16:20 - 16:40 (CET)
The Metabolite Path to Vitality: Detecting, Predicting, and Reversing Gut Inflammation
Nika Pintar , Chief at Ani Biome, Croatia
10:40 - 11:00 AM (NY)
16:40 - 17:00 (CET)
16:40 - 17:00 (CET)
Improving regeneration of aged muscle
Pura Muñoz-Canoves, Altos Labs, USA
11:00 - 11:20 PM (NY)
17:00 - 17:20 (CET)
17:00 - 17:20 (CET)
Targeting Healthy Longevity
Brian Kennedy , NUS, Singapore
11:20 - 11:40 AM (NY)
17:20 - 17:40 (CET)
17:20 - 17:40 (CET)
Coffee break
11:40 - 12:20 AM (NY)
17:40 - 18:20 (CET)
17:40 - 18:20 (CET)
Indications for longevity biotech: Pharma partnership for age-related drug discovery
Moderated by Kristen Fortney
Peng Leong, BioAge Labs, Inc., USA
Benjamin Yaden, Eli Lilly and Company, USA
Erik Vernet, Novo Nordisk, Denmark
12:20 - 13:00 (NY)
18:20 - 19:00 (CET)
18:20 - 19:00 (CET)
Dinner
01:00 - 01:20 PM (NY)
19:00 - 19:20 (CET)
19:00 - 19:20 (CET)
Unlocking the secrets of senescence: how sub-lethal apoptotic stress unleashes the SASP
João Passos, Mayo Clinic, USA
01:20 - 01:40 PM (NY)
19:20 - 19:40 (CET)
19:20 - 19:40 (CET)
Lene Juel Rasmussen, Center for Healthy Aging, University of Copenhagen, Denmark
01:40 - 02:00 PM (NY)
19:40 - 20:00 (CET)
19:40 - 20:00 (CET)
Final Line, Final Talk: Defying Time, Defying the Clock
Vadim Gladyshev , Harvard Medical School, USA
02:00 - 02:10 PM (NY)
20:00 - 20:10 (CET)
20:00 - 20:10 (CET)
Wrap up
02:10 - 08:00 PM (NY)
20:10 - 02:00 (CET)
20:10 - 02:00 (CET)
Drinks and socializing in Bar7