Emerging Tech Workshop
Monday, August 29
08:00 - 9:00 (CET)
Registration & Breakfast
09:00 - 9:05 (CET)
Welcome to the workshop
Morten Scheibye-Knudsen, University of Copenhagen
Dr. Alex Zhavoronkov, PhD, Founder and CEO, Insilico Medicine
Maximilian Unfried, National University of Singapore, University of Copenhagen, VitaDAO
09:05 - 10:10 (CET)
Session 1: AI, Computation and Automation in Biomedical Research
Michael A. Petr, Tracked.bio, Denmark
Dr. Alex Zhavoronkov, PhD, Founder and CEO, Insilico Medicine
Andreas Mund, Associate Professor, Clinical Proteomics at the Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research
Maximilian Unfried, National University of Singapore, University of Copenhagen, VitaDAO
10:10-10:30 (CET)
Break
10:30-11:50 (CET)
Session 2: Decentralized Science and Blockchain in Aging Research
Tim Peterson, VitaDAO
Sebastian A. Brunemeier, General Partner at Healthspan Capital, Advisor to Molecule AG and VitaDAO
Garri Zmudze, LongeVC, Switzerland
Stephanie Dainow, Lifespan.io, USA
11:50-12:30 (CET)
Hands on Break-out Sessions on the Booths
Longevity Medicine Workshop
Monday, August 29
13:00 (CET)
Welcome to the workshop
Dr. Evelyne Bischof, Human Longevity Inc./Shanghai University of Medicine and Health Sciences
Dr. Sebastien Thuault, PhD, Chief Editor, Nature Aging
Dr. Alex Zhavoronkov, PhD, Founder and CEO, Insilico Medicine
Morten Scheibye-Knudsen, University of Copenhagen
13:30 (CET)
Lecture session 1
Victor J. Dzau, President of the United States National Academy of Medicine, USA
Dr. Mehmood Khan, CEO, Hevolution Foundation, Saudi Arabia
Felipe Sierra, PhD, Hevolution Foundation, Saudi Arabia
Dr. James Kirkland, MD, PhD, Noaber Foundation
Professor of Aging Research
Director, Robert and Arlene Kogod Center on Aging
15:00 (CET)
Lecture session 2
Dr. Evelyne Bischof, MD, Human Longevity Inc.
Shanghai University of Medicine and Health Sciences
Dr. Andrea B. Maier, Oon Chiew Seng Professor,
Co-Director Centre for Healthy Longevity, National University of Singapore; Professor of Gerontology, Vrije Universiteit Amsterdam
Dr. Joan Mannick, Co-Founder and CEO, Tornado Therapeutics
Dr. Nir Barzilai, Albert Einstein College of Medicine
16:45 (CET)
Strategic debate "What is needed to translate geroscience into the clinic?"
Dr. James Kirkland, MD, PhD, Noaber Foundation
Professor of Aging Research
Director, Robert and Arlene Kogod Center on Aging
Dr. Evelyne Bischof, MD, Human Longevity Inc.
Shanghai University of Medicine and Health Sciences
Dr. Mehmood Khan, CEO, Hevolution Foundation, Saudi Arabia
Felipe Sierra, PhD, Hevolution Foundation, Saudi Arabia
Dr. Andrea B. Maier, Oon Chiew Seng Professor,
Co-Director Centre for Healthy Longevity, National University of Singapore; Professor of Gerontology, Vrije Universiteit Amsterdam
Dr. Wei-Wu He, PhD, MBA Executive Chairman and CEO of Human Longevity
17:45 (CET)
Strategic debates Longevity medicine therapeutics: applied geroprotective interventions, drug repurposing and discovery, RCTs
Dr. Matt Kaeberlein, Professor of Laboratory Medicine and Pathology,
Adjunct Professor of Genome Sciences,
Adjunct Professor of Oral Health Sciences, University of Washington
Dr. Nir Barzilai, Albert Einstein College of Medicine
Dr. Eric Verdin, Buck Institute
Dr. Kristen Fortney, BioAge Labs, Inc.
Dr. Alex Zhavoronkov, PhD, Founder and CEO, Insilico Medicine
Dr. Joan Mannick, Co-Founder and CEO, Tornado Therapeutics
18:45(CET)
Strategic debates Longevity medicine diagnostics and innovations (inpatient, outpatient, self-monitoring, POC, liquid biopsies, "pan"-panels, imaging; integration and current applicability)
Christine Huang, Hong Kong Quantum AI Lab, Hong Kong
Prof. Tzipora Strauss, MD, Chaim Sheba Medical Center, Tel Hashomer, Israel
Dr. Dina Radenkovic, Co-founder & CEO of Gameto
Prof. Joerg Goldhahn, MD
Joanna Bensz, Co-founder and CEO, Longevity Center
CEO, International Institute of Longevity
Luc J.C. van Loon, Professor, Department of Human Biology, Maastricht University Medical Centre
19:30(CET)
Strategic debates Open floor discussion - Synthesis of the Meeting, Take Home Message and the Big Questions
Program ARDD 2022
Tuesday, August 30
03:00 - 04:15 (NY)
9:00 - 10:15 (CET)
Registrations, coffee, tea
04:15 - 04:30 (NY)
10:15 - 10:30 (CET)
Welcome!
Morten Scheibye-Knudsen, University of Copenhagen
Bente Merete Stallknecht, The Dean of the University of Copenhagen
04:30 - 04:50 (NY)
10:30 - 10:50 (CET)
Drugging the nutrient-sensing network
Linda Partridge, Max Planck Institute for Biology of Aging
04:50 - 05:10 (NY)
10:50 - 11:10 (CET)
Chemical interventions in aging promoting Healthspan
Gordon Lithgow, Buck Institute
05:10 - 05:30 (NY)
11:10 - 11:30 (CET)
Omics studies of Drosophila aging and longevity
Alexey Moskalev, George Mason University
05:30 - 06:45 (NY)
11:30 - 12:45 (CET)
ARDD EARLY CAREER BREAK-OUT LUNCH
Munkekælderen, University of Copenhagen
Moderators:
Brenna Osborne, Assistant Professor, University of Copenhagen, Denmark
Nathan Cheng, Program Director, On Deck Longevity Biotech, Canada
Panelists:
Kristen Fortney, BioAge Labs, Inc., USA
James Peyer, Cambrian Biopharma, USA
Jennifer Garrison, Buck Institute, USA
Sam Sharifi, Matter Bioworks
07:00 - 07:20 (NY)
13:00 - 13:20 (CET)
Tissue immunology and repair across lifespan
Jennifer H. Elisseeff, Johns Hopkins University
07:20 - 07:40 (NY)
13:20 - 13:40 (CET)
The biochemistry that unites infectious disease and aging
Tim Peterson, VitaDAO
07:40 - 08:00 (NY)
13:40 - 14:00 (CET)
The Emerging Commercial Landscape for Aging Biology-Based Therapeutics
Michael Ringel, BCG, USA
08:00 - 08:20 (NY)
14:00 - 14:20 (CET)
Coffee break
08:20 - 08:40 (NY)
14:20 - 14:40 (CET)
An update on Geroscience approaches to treat age-related diseases
Laura Niedernhofer, University of Minnesota, USA
08:40 - 09:00 (NY)
14:40 - 15:00 (CET)
Unifying mechanism for nuclear and mitochondrial progerias in mice: challenged nuclear DNA integrity in stem cells
Anu Suomalainen, University of Helsinki
09:00 - 09:20 (NY)
15:00 - 15:20 (CET)
NAD+ precursors: exploring the old and the new
Carles Canto, Nestlé Institute of Health Sciences
09:20 - 10:00 (NY)
15:20 - 16:00 (CET)
Poster setup
10:00 - 10:20 (NY)
16:00 - 16:20 (CET)
Modifying protein toxicity in ageing and age-related diseases
Ellen Nollen, ERIBA
10:20 - 10:40 (NY)
16:20 - 16:40 (CET)
Regulation of stem cell biology by interferons independent of antiviral function
Ana Martin-Villalba, German Cancer Research Center
10:40 - 11:00 (NY)
16:40 - 17:00 (CET)
Myokine-based interventions to contrast muscle and brain aging
Fabio Demontis, St. Jude Children's Research Hospital
11:00 - 11:20 (NY)
17:00 - 17:20 (CET)
Coffee break
11:20 - 11:40 (NY)
17:20 - 17:40 (CET)
Immunometabolic checkpoints of aging: Lessons from CALERIE
Vishwa Dixit, Yale School of Medicine, USA
11:40 - 12:00 (NY)
17:40 - 18:00 (CET)
Beyond the Calorie: The regulation of health and longevity by a specific dietary amino acid
Dudley Lamming, University of Wisconsin-Madison, USA
12:00 - 12:20 (NY)
18:00 - 18:20 (CET)
Targeting aging with rapamycin: On the path toward 21st Century Medicine
Matt Kaeberlein, University of Washington, USA
12:20 - 13:00 (NY)
18:20 - 19:00 (CET)
Dinner
13:00 - 13:20 (NY)
19:00 - 19:20 (CET)
A lipid switch promoting cytokinesis eventually prevents senescence and cataract
Emilio Hirsch, University of Torino, Italy
13:20 - 13:40 (NY)
19:20 - 19:40 (CET)
From Single Cell AI-enabled Discovery of Cellular Senescence to Targeted Senolytic Drug Development
Marco Quarta, Rubedo Life Sciences, USA
13:40 - 14:00 (NY)
19:40 - 20:00 (CET)
Quantifying aging and rejuvenation
Judith Campisi, Buck Institute, USA
14:00 - 15:00 (NY)
20:00 - 21:00 (CET)
Poster session
15:00 - 20:00 (NY)
21:00 - 02:00 (CET)
Drinks and socializing at Bar7

Wednesday, August 31
02:00 - 03:00 (NY)
8:00 - 09:00 (CET)
Registrations, coffee, tee
03:00 - 03:10 (NY)
09:00 − 09:10 (CET)
Welcome!
03:10 - 03:30 (NY)
09:10 - 09:30 (CET)
Genome Stability in Aging and Disease: New insights from C. elegans
Björn Schumacher, University of Cologne, Germany
03:30 - 03:50 (NY)
09:30 - 09:50 (CET)
Bringing Geroscience into clinical practice: from diagnostics to interventions, and, the Longevity Medicine Society
Andrea Maier, National University of Singapore, Singapore
03:50 - 04:10 (NY)
09:50 - 10:10 (CET)
Chromosome instability as a driver of human disease
Ian Hickson, University of Copenhagen, Denmark
04:10 - 04:30(NY)
10:10 - 10:30 (CET)
Break
04:30 - 04:50 (NY)
10:30 - 10:50 (CET)
Single cell and Deep Visual Proteomics and its applications in precision medicine
Matthias Mann, Max Planck Institute for Biochemistry, Germany
04:50 - 05:10 (NY)
10:50 - 11:10 (CET)
Optimizing translatability of drug discovery for diseases of aging
Martin Borch Jensen, Gordian Biotechnology, USA
05:10 - 05:30(NY)
11:10 - 11:30 (CET)
A case study of the application of Pharma.AI platform for discovery and development of dual-purpose therapeutics targeting aging and disease
Alex Zhavoronkov, Insilico Medicine, Hong Kong
05.30 - 07.00(NY)
11:30 - 13:00 (CET)
Lunch and break-out lunch with Vadim Gladyshev, Matt Kaeberlein and Andrea Maier: What is aging?
07:00 - 07:20 (NY)
13:00 - 13:20 (CET)
Identification and functional characterisation of genetic variants linked to human longevity
Joris Deelen, Max Planck Institute for Biology of Ageing, Germany
07:20 - 07:40 (NY)
13:20 - 13:40 (CET)
Multi-Omic Trained Biological Age and Death Predictor and New Epigenetic Insights from 2022
Varun Dwaraka, TruDiagnostic, USA
07:40 - 08:00 (NY)
13:40 - 14:00 (CET)
Human biological aging and drug treatment effects
Sara Hägg, Karolinska Institutet, Sweden
08:00 - 08:20 (NY)
14:00 - 14:20 (CET)
Coffee break
08:20 – 08:35 (NY)
14:20 − 14:35 (CET)
The IL11/ERK/mTOR axis of senescence is a therapeutic target for extending mammalian healthspan
Stuart Cook, Duke-NUS Medical School, Singapore
08:35 – 08:50 (NY)
14:35 − 14:50 (CET)
Decreased spliceosome fidelity inhibits mTOR signalling to promote longevity
Wenming Huang, Postdoc researcher in Dr.Adam Antebi's group in Max Planck Institute for Biology of Ageing, Germany
08:50 – 09:05 (NY)
14:50 − 15:05 (CET)
Inhibition of S6K benefits age-related immune dysfunctions and increases lifespan via the endolysosomal system
Pingze Zhang, Max Planck Institute for Biology of Ageing
09:05 – 09:20 (NY)
15:05 − 15:20 (CET)
A lysosomal surveillance response (LySR) that extends healthspan
Arwen Gao, Amsterdam UMC
09:20 - 10:00 (NY)
15:20 - 16.00 (CET)
Poster session
10:00 - 10:20 (NY)
16:00 - 16:20 (CET)
Reframing Health and Aging through the Lens of Reproductive Longevity
Jennifer Garrison, Buck Institute for Research on Aging, USA
10:20 - 10:40 (NY)
16:20 - 16:40 (CET)
Therapeutic Advances in Female Reproductive Longevity
Dina Radenkovic, Gameto, USA
10:40 - 11:00 (NY)
16:40 - 17:00 (CET)
Sarah Mitchell, ETH Zurich
11:00 - 11:20 (NY)
17:00 - 17:20 (CET)
Coffee break
11:20 - 11:40 (NY)
17:20 - 17:40 (CET)
Longevity enriched families. How did they succeed?
Kaare Christensen, Danish Aging Research Center and the Danish Twin Registry, Denmark
11:40 - 12:00 (NY)
17:40 - 18:00 (CET)
Morgan Levine, Yale School of Medicine, USA
12:00 - 12:20 (NY)
18:00 - 18:20 (CET)
Nir Barzilai, Albert Einstein College of Medicine, USA
12:20 - 01:00 (NY)
18:20 - 19:00 (CET)
Dinner
13:00 - 14:00 (NY)
19:00-20:00 (CET)
VC Panel: Investing in Longevity Biotechnology
Alexandra Bause, Apollo Health Ventures, USA
Alex Zhavoronkov, Insilico Medicine, Hong Kong
Mehmood Khan, CEO of Hevolution Foundation, Saudi Arabia
James Peyer, Cambrian Biopharma, USA
Anastasia Georgievskaya, Haut.AI,Estonia
Laurence Ion, VitaDAO
Kristen Fortney, BioAge Labs, Inc., USA
Garri Zmudze, LongeVC, Switzerland
14:00 - 15:00 (NY)
20:00 - 21:00 (CET)
Poster session
15:00 - 20:00 (NY)
21:00 - 02:00 (CET)
Drinks and socializing in Bar7

Thursday, September 1
03:00 - 04:15 (NY)
9:00 - 10:25 (CET)
Registrations, coffee, tee
04:15 - 04:30 (NY)
10:25 - 10:30 (CET)
Welcome!
04:30 - 04:50 (NY)
10:30 - 10:50 (CET)
Cross species of genetics to identify targets in mitochondria and aging
Johan Auwerx, Ecole Polytechnique Fédérale Lausanne (EPFL), Switzerland
04:50 - 05:10 (NY)
10:50 - 11:10 (CET)
Metabolic impact of manipulating NAD+ biosynthesis capacity in young and old
JonasTreebak, University of Copenhagen, Denmark
05:10 - 05:30 (NY)
11:10 - 11:30 (CET)
A Novel DNA Methylation Clock Resilient to Changes in Immune Composition
Eric Verdin, Buck Institute, USA
05:30 - 07:00
11:30 - 13:00 (CET)
Inspire Longevity Lunch with Andrea Olsen and Zachary Harpaz
07:00 - 07:20 (NY)
13:00 - 13:20 (CET)
Decentralized Science: Early Learnings and Future Hopes
Tyler Golato, Molecule, Switzerland
07:20 - 07:40 (NY)
13:20 - 13.40 (CET)
IgG glycans as biomarkers of health and ageing
Marina Martinić Kavur, GlycanAge, England
07:40 - 08:00 (NY)
13:40 - 14:00 (CET)
Plasma Proteomics Signatures of Cardiometabolic Aging
Anders Malarstig, Director at Pfizer, USA
08:00 - 08:20 (NY)
14:00 - 14:20 (CET)
Coffee break
08:20 - 08:35 (NY)
14:20 − 14:35 (CET)
Deletion of the mitochondrial dynamics gene leads to a segmental progeria in mice
Olga Bielska, Buck Institute for Research on Aging, California, USA
08:35 - 08:50 (NY)
14:35 − 14:50 (CET)
Geroprotective effects of the small molecule
PGC-1⍺ modulator TQS-168
Jonas Hannestad, Tranquis Therapeutics, USA
08:50 - 09:05 (NY)
14:50 − 15:05 (CET)
Energy replacement: Harnessing the energy of light into mitochondrial chemical energy increase lifespan
Shahaf Peleg, FBN, Germany
09:05 - 09:20 (NY)
15:05 − 15:20 (CET)
Anti-retroviral treatment with zidovudine reduces translation and extends healthy longevity via ATF-4
Rebecca McIntyre, Amsterdam UMC
09:20 - 10:00 (NY)
15:20 - 16:00 (CET)
Poster session
10:00 - 10:20 (NY)
16:00 - 16.20 (CET)
Pekka Katajisto, University of Helsinki, Finland
10:20 - 10:40 (NY)
16:20 - 16:40 (CET)
Muscle stem cells in age and disease
Julia von Maltzahn, Fritz Lipmann Institute, Germany
10:40 - 11:00 (NY)
16:40 - 17:00 (CET)
Innovations and moonshots in longevity biotech
James Peyer, Cambrian Biopharma, USA
11:00 - 11:20 (NY)
17:00 - 17:20 (CET)
Coffee break
11:20 - 11:40 (NY)
17:20 - 17:40 (CET)
Telomeres & diseases of aging: the root of all evil and what we can do about it
Fabrizio d'Adda di Fagagna, National Research Council, Italy
11:40 - 12:00 (NY)
17:40 - 18:00 (CET)
The Genetic medicine platform for longevity
Matthew Scholz, Oisin Bio, USA
12:00 - 12:20 (NY)
18:00 - 18:20 (CET)
Age Better, Live longer, with Rejuveron Life Sciences
Stephen Helliwell, Rejuveron, Switzerland
12:20 - 13:00 (NY)
18:20 - 19:00 (CET)
Dinner
13.00 - 13:20 (NY)
19:00 - 19:20 (CET)
Circadian Clocks and their Impact on Metabolism, Aging and Longevity
Joseph Takahashi, University of Texas Southwestern Medical Center, USA
13:20 - 13:40 (NY)
19:20 - 19:40 (CET)
Out with the Bad: Clearing Progeronic Soluble Factors with NaNots
Lou Hawthorne, NaNotics LLC, USA
13:40 - 14:00 (NY)
19:40 - 20.00 (CET)
Rafael de Cabo, NIA-NIH, USA
14:00 - 14:20 (NY)
20:00 - 20.20 (CET)
Break
14:20 - 14:40 (NY)
20:20 - 20:40 (CET)
Developing cell reprogramming based strategies for healthy aging
Jean-Marc Lemaitre, Institute of Regenerative Medicine and Biotherapies of Montpellier, France
14:40 - 15:00 (NY)
20:40 - 21:00 (CET)
What do reprogramming, parabiosis, and autophagy have in common?
Joe Betts-LaCroix, Retro Biosciences, USA
15:00 - 15:20 (NY)
21:00 − 21:20 (CET)
David Sinclair, Harvard Medical School, USA
14.00 - 20:00 (NY)
20:00 - 02:00 (CET)
Drinks and socializing in Bar7

Friday, September 2
03:30 - 04:15 (NY)
9:30 - 10:15 (CET)
Registrations, coffee, tee
04:15 - 04:30 (NY)
10:15 - 10:30 (CET)
Welcome and Poster Award ceremony
04:30 - 04:50 (NY)
10:30 - 10:50 (CET)
Genome maintenance mechanisms in aging
Morten Scheibye-Knudsen, University of Copenhagen, Denmark
04:50 - 05:10 (NY)
10:50 - 11:10 (CET)
Platform-based clinical development in aging
Ann Beliën, Rejuvenate Biomed
05:10 - 05:30 (NY)
11:10 - 11:30 (CET)
Overview of incretin based therapies of metabolic disease
Jens Juul Holst, University of Copenhagen, Denmark
05:30 - 07:00 (NY)
11:30 - 13:00 (CET)
Lunch
07:00 - 07:20 (NY)
13:00 - 13:20 (CET)
Epigenetic Aging Studies in Humans and Other Mammals
Steve Horvath, Altos Labs, San Diego, CA
07:20 - 07:40 (NY)
13:20 - 13:40 (CET)
Neuronal blood markers to predict mortality in old age
Mathias Jucker, DZNE, Germany
07:40 - 08:00 (NY)
13:40 - 14:00 (CET)
A case study of the application of PandaOmics platform for discovery and development of dual-purpose therapeutics targeting aging and disease
Quentin Vanhaelen, Insilico Medicine
08:00 - 08.20 (NY)
15:20 - 16:00 (CET)
Coffee break
08:20 - 08:35 (NY)
14:20 - 14:35 (CET)
Vascular aging limits metastasis
Ashik Ahmed Abdul Pari, German Cancer Research Institute, German
08:35 - 08:50 (NY)
14:35 - 14:50 (CET)
Deletion of the RNA methyltransferase Nsun5 reduces frailty in mice
Markus Schosserer, Medical University of Vienna
08:50 - 09:05 (NY)
14:50 - 15:05 (CET)
A concerted increase in intron retention and readthrough drives transposon expression during aging and senescence
Kamil Pabis, National University of Singapore, Singapore
09:05 - 09:20 (NY)
15:05 - 15:20 (CET)
Mouse transcriptomic clocks of biological age and lifespan characterize rejuvenation strategies and predict longevity interventions
Alexander Tyshkovskiy, Harvard Medical School, USA
09.20 - 10:00 (NY)
15:20 - 16:00 (CET)
Coffee break
10:00 - 10:20 (NY)
16:00 - 16:20 (CET)
Heterogeneity in cellular senescence: from mechanisms to interventions
Marco Demaria, ERIBA, The Netherlands
10:20 - 10:40 (NY)
16:20 - 16:40 (CET)
Text mining pathology reports and machine learning driven interventions for aging
Michael Ben Ezra, University of Copenhagen, Denmark
10:40 - 11:00 (NY)
16:40 - 17:00 (CET)
DNA damage signaling to mitochondria in neurodegeneration and aging
Vilhelm Bohr, National Institute on Aging, USA
11:00 - 11:20 (NY)
17:00 - 17:20 (CET)
Coffee break
11:20 - 11:40 (NY)
17:20 - 17:40 (CET)
Interventions, Diagnostics and Functional Decline – Connecting the Dots
Brian Kennedy, National University of Singapore, Singapore
11:40 - 12:00 (NY)
17:40 - 18:00 (CET)
Data-driven approaches in longevity pharmacology
Joao Pedro de Magalhaes, University of Liverpool, UK
12:00 - 12:20 (NY)
18:00 - 18:20 (CET)
Data-informed drug discovery and clinical development for therapies that target aging
Eric Morgen, BioAge Labs, Inc., USA
12:20 - 13:00 (NY)
18:20 - 19:00 (CET)
Dinner
13.00 -13:20 (NY)
19:00 - 19:20 (CET)
Quantifying aging and rejuvenation
Vadim Gladyshev, Harvard, USA
13:20 - 13:40 (NY)
19:20 - 19:40 (CET)
Bats hold the secret of extended healthspan
Emma Teeling, University College Dublin, Ireland
13:40 - 14:00 (NY)
19:40 - 20.00 (CET)
Mechanisms of longevity and epigenome stability
Vera Gorbunova, University of Rochester, USA
14.00 - 14:10 (NY)
20:00 - 20:10 (CET)
Wrap up
15.00 - 20:00 (NY)
20:00 - 02:00 (CET)
Drinks and socializing in Bar7